Dataset: theoph.dat Source: K. Bachmann, T.J. Sullivan, J.H. Reese, et al. (1995). "Controlled Study of the Putative Interaction Between Famotidine and Theophylline in Patients with Chronic Obstructive Pulmonary Disorder," Journal of Clinical Pharmacology, 35:529-535. Description: Randomized Block design in 14 patients with chronic obstructive pulmonary disease. Each subject received theophylline along with (famotidine(pepcid), cimetidine(tagamet), placebo) and theophylline clearance (liters/hour) was measured. Variables/Columns Subject Number 8 Interacting agent 16 /* 1=Placebo, 2=Pepcid, 3=Tagamet */ Theophylline clearance (ltr/hr) 21-24